Peter Nagy

pdnagy2@uky.edu
Phone (859) 218-0726
Fax (859) 323-1961
Nagy Lab

Department of Plant Pathology
221 Plant Science Building
Lexington KY 40546-0312

Professional Profile

Professor


Focus

Research

  • Virus replication: We use Tombus viruses, small model RNA viruses of plants, to identify the viral and host players in replication and to unravel the mechanism of virus replication.
  • Virus recombination: To understand the mechanism of virus evolution


Teaching

  • PPA 671: Advanced Plant Virology

Education

  • Ph.D. in Plant Protection, 1990, Hungarian Academy of Sciences, Institute of Plant Protection, Budapest
  • B.Sc. and M.S. in Plant Protection, 1985, Agricultural University of Keszthely, Hungary


Employment Highlights

  • Professor, University of Kentucky, 2007 to present
  • Associate Professor, University of Kentucky, 2003-2007
  • Assistant Professor, University of Kentucky, 1999-2003
  • Research Associate, University of Massachusetts, 1996-1998
  • Research Associate, Northern Illinois Universtiy, 1990-1995
  • Postdoctoral Fellow, University of Bari, Italy, 1990 

Awards, Recognition, Service

2008 to present

  • Prestigious Paper Award, UK College of Agriculture, Food and Environment, 2016
  • Bobby Pass Excellence in Grantmanship Award, 2013
  • Smith fellow lecturer, University of British Columbia, Vancouver, Canada, 2011
  • Breakthrough paper on virus replication (Wang, and Nagy, P. D.) was selected in the “SPOTLIGHT” by Journal of Virology, the leading journal in the field of virology, 2009

Recent Research Publications

2016 to present (see Nagy Lab pages for a more complete list)

  • Xu, K., and P. D. Nagy. 2017. Sterol Binding by the Tombusviral Replication Proteins Is Essential for Replication in Yeast and Plants. J Virol 91.
  • Prasanth, K. R., C. Chuang, and P. D. Nagy. 2017. Co-opting ATP-generating glycolytic enzyme PGK1 phosphoglycerate kinase facilitates the assembly of viral replicase complexes. PLoS Pathog 13:e1006689.
  • Nagy, P. D. 2017. Exploitation of a surrogate host, Saccharomyces cerevisiae, to identify cellular targets and develop novel antiviral approaches. Curr Opin Virol 26:132-140.
  • Kovalev, N., J. I. Inaba, Z. Li, and P. D. Nagy. 2017. The role of co-opted ESCRT proteins and lipid factors in protection of tombusviral double-stranded RNA replication intermediate against reconstituted RNAi in yeast. PLoS Pathog 13:e1006520.
  • Fernandez de Castro, I., J. J. Fernandez, D. Barajas, P. D. Nagy, and C. Risco. 2017. Three-dimensional imaging of the intracellular assembly of a functional viral RNA replicase complex. J Cell Sci 130:260-268.
  • Chuang, C., K. R. Prasanth, and P. D. Nagy. 2017. The Glycolytic Pyruvate Kinase Is Recruited Directly into the Viral Replicase Complex to Generate ATP for RNA Synthesis. Cell Host Microbe 22:639-652 e7.
  • Xu, K., and P. D. Nagy. 2016. Enrichment of Phosphatidylethanolamine in Viral Replication Compartments via Co-opting the Endosomal Rab5 Small GTPase by a Positive-Strand RNA Virus. PLoS Biol 14:e2000128.
  • Prasanth, K. R., N. Kovalev, I. F. de Castro Martin, J. Baker, and P. D. Nagy. 2016. Screening a yeast library of temperature-sensitive mutants reveals a role for actin in tombusvirus RNA recombination. Virology 489:233-242.
  • Nawaz-Ul-Rehman, M. S., K. R. Prasanth, K. Xu, Z. Sasvari, N. Kovalev, I. F. de Castro Martin, D. Barajas, C. Risco, and P. D. Nagy. 2016. Viral Replication Protein Inhibits Cellular Cofilin Actin Depolymerization Factor to Regulate the Actin Network and Promote Viral Replicase Assembly. PLoS Pathog 12:e1005440.
  • Nagy, P. D., J. R. Strating, and F. J. van Kuppeveld. 2016. Building Viral Replication Organelles: Close Encounters of the Membrane Types. PLoS Pathog 12:e1005912.
  • Nagy, P. D., J. Pogany, and K. Xu. 2016. Cell-Free and Cell-Based Approaches to Explore the Roles of Host Membranes and Lipids in the Formation of Viral Replication Compartment Induced by Tombusviruses. Viruses 8
  • Nagy, P. D. 2016. Tombusvirus-Host Interactions: Co-Opted Evolutionarily Conserved Host Factors Take Center Court. Annu Rev Virol 3:491-515.
  • Kovalev, N., I. F. de Castro Martin, J. Pogany, D. Barajas, K. Pathak, C. Risco, and P. D. Nagy. 2016. Role of Viral RNA and Co-opted Cellular ESCRT-I and ESCRT-III Factors in Formation of Tombusvirus Spherules Harboring the Tombusvirus Replicase. J Virol 90:3611-26.