Peter Nagy

pdnagy2@uky.edu
Phone (859) 218-0726
Fax (859) 323-1961
Nagy Lab

Department of Plant Pathology
221 Plant Science Building
Lexington KY 40546-0312

Professional Profile

Professor


Focus

Research

  • Virus replication: We use Tombus viruses, small model RNA viruses of plants, to identify the viral and host players in replication and to unravel the mechanism of virus replication.
  • Virus recombination: To understand the mechanism of virus evolution


Teaching

  • PPA 671: Advanced Plant Virology

Education

Ph.D. in Plant Protection, 1990, Hungarian Academy of Sciences, Institute of Plant Protection, Budapest
B.Sc. and M.S. in Plant Protection, 1985, Agricultural University of Keszthely, Hungary


Employment Highlights

  • Professor, University of Kentucky, 2007 to present
  • Associate Professor, University of Kentucky, 2003-2007
  • Assistant Professor, University of Kentucky, 1999-2003
  • Research Associate, University of Massachusetts, 1996-1998
  • Research Associate, Northern Illinois Universtiy, 1990-1995
  • Postdoctoral Fellow, University of Bari, Italy, 1990 

Awards, Recognition, Service

2008 to present

  • Bobby Pass Excellence in Grantmanship Award, 2013
  • Smith fellow lecturer, University of British Columbia, Vancouver, Canada, 2011
  • Breakthrough paper on virus replication (Wang, and Nagy, P. D.) was selected in the “SPOTLIGHT” by Journal of Virology, the leading journal in the field of virology, 2009

Recent Research Publications

2014 to present (see also Nagy Lab pages for a more complete list)

  • Xu, K., and P. D. Nagy. 2015. RNA virus replication depends on enrichment of phosphatidylethanolamine at replication sites in subcellular membranes. Proc Natl Acad Sci U S A 112:E1782-E1791.
  • Tian, M., Z. Sasvari, P. A. Gonzalez, G. Friso, E. Rowland, X. M. Liu, K. J. van Wijk, P. D. Nagy, and D. F. Klessig. 2015. Salicylic Acid Inhibits the Replication of Tomato bushy stunt virus by Directly Targeting a Host Component in the Replication Complex. Mol Plant Microbe Interact 28:379-86.
  • Prasanth, K. R., D. Barajas, and P. D. Nagy. 2015. The Proteasomal Rpn11 Metalloprotease Suppresses Tombusvirus RNA Recombination and Promotes Viral Replication via Facilitating Assembly of the Viral Replicase Complex. J Virol 89:2750-63.
  • Pogany, J., and P. D. Nagy. 2015. Activation of Tomato Bushy Stunt Virus RNA-Dependent RNA Polymerase by Cellular Heat Shock Protein 70 Is Enhanced by Phospholipids In Vitro. J Virol 89:5714-23.
  • Nagy, P. D. 2015. Viral Sensing of the Subcellular Environment Regulates the Assembly of New Viral Replicase Complexes during the Course of Infection. J Virol 89:5196-5199.
  • Chuang, C., K. R. Prasanth, and P. D. Nagy. 2015. Coordinated Function of Cellular DEAD-Box Helicases in Suppression of Viral RNA Recombination and Maintenance of Viral Genome Integrity. PLoS Pathog 11:e1004680.
  • Barajas, D., N. Kovalev, J. Qin, and P. D. Nagy. 2015. Novel Mechanism of Regulation of Tomato Bushy Stunt Virus Replication by Cellular WW-Domain Proteins. J Virol 89:2064-79.
  • Xu, K., and P. D. Nagy. 2014. Expanding use of multi-origin subcellular membranes by positive-strand RNA viruses during replication. Curr Opin Virol 9C:119-126.
  • Xu, K., J. Y. Lin, and P. D. Nagy. 2014. The hop-like stress-induced protein 1 cochaperone is a novel cell-intrinsic restriction factor for mitochondrial tombusvirus replication. J Virol 88:9361-78.
  • Sasvari, Z., P. Alatriste Gonzalez, and P. D. Nagy. 2014. Tombusvirus-yeast interactions identify conserved cell-intrinsic viral restriction factors. Front Plant Sci 5:383.
  • Nagy, P. D., J. Pogany, and J. Y. Lin. 2014. How yeast can be used as a genetic platform to explore virus-host interactions: from 'omics' to functional studies. Trends Microbiol 22:309-316.
  • Li, Z., P. A. Gonzalez, Z. Sasvari, T. G. Kinzy, and P. D. Nagy. 2014. Methylation of translation elongation factor 1A by the METTL10-like See1 methyltransferase facilitates tombusvirus replication in yeast and plants. Virology 448C:43-54.
  • Kovalev, N., J. Pogany, and P. D. Nagy. 2014. Template role of double-stranded RNA in tombusvirus replication. J Virol 88:5638-51.
  • Kovalev, N., and P. D. Nagy. 2014. The Expanding Functions of Cellular Helicases: The Tombusvirus RNA Replication Enhancer Co-opts the Plant eIF4AIII-Like AtRH2 and the DDX5-Like AtRH5 DEAD-Box RNA Helicases to Promote Viral Asymmetric RNA Replication. PLoS Pathog 10:e1004051.
  • Chuang, C., D. Barajas, J. Qin, and P. D. Nagy. 2014. Inactivation of the Host Lipin Gene Accelerates RNA Virus Replication through Viral Exploitation of the Expanded Endoplasmic Reticulum Membrane. PLoS Pathog10:e1003944.
  • Barajas, D., K. Xu, M. Sharma, C. Y. Wu, and P. D. Nagy. 2014. Tombusviruses upregulate phospholipid biosynthesis via interaction between p33 replication protein and yeast lipid sensor proteins during virus replication in yeast. Virology 471-473C:72-80.
  • Barajas, D., K. Xu, I. F. de Castro Martin, Z. Sasvari, F. Brandizzi, C. Risco, and P. D. Nagy. 2014. Co-opted Oxysterol-Binding ORP and VAP Proteins Channel Sterols to RNA Virus Replication Sites via Membrane Contact Sites. PLoS Pathog 10:e1004388.
  • Barajas, D., I. F. Martin, J. Pogany, C. Risco, and P. D. Nagy. 2014. Noncanonical Role for the Host Vps4 AAA+ ATPase ESCRT Protein in the Formation of Tomato Bushy Stunt Virus Replicase. PLoS Pathog 10:e1004087.
  • Shah Nawaz-Ul-Rehman, M., K. Reddisiva Prasanth, J. Baker, and P. D. Nagy. 2013. Yeast screens for host factors in positive-strand RNA virus replication based on a library of temperature-sensitive mutants. Methods59:207-16.
  • Sasvari, Z., N. Kovalev, and P. D. Nagy. 2013. The GEF1 Proton-Chloride Exchanger Affects Tombusvirus Replication via Regulation of Copper Metabolism in Yeast. J Virol 87:1800-10.