Research Projects

In order to establish successful infections, viruses must divert, commandeer, or inhibit cellular functions to their advantage while concomitantly avoiding defense responses mounted by host cells.  Our research projects primarily involve the study of the plant-adapted members of the family Rhabdoviridae, which contains enveloped viruses with monopartite, minus-sense, single-stranded RNA genomes.  Our primary research models, Sonchus yellow net virus (SYNV) and Potato yellow dwarf virus (PYDV) replicate in nuclei of infected cells.  For this reason, we are very interested in characterization of the nucleome. Additionally, we are identifying host factors required for rhabdoviral replication and cell-to-cell movement.